Correlation of maternal age and combined assessments on risk of chromosomal anomaly during prenatal screening

Background: Prenatal detection of genetic abnormalities is one the biggest challenges current fetal medicine. screening for chromosomal can be done using biochemical tests. The a risk estimation test and not diagnostic test. Methods: Statistical data treatment had been performed on sample 362 pregnant women prenatal screening. This was retrospective analysis study undertaken at National Reference Laboratory, Redcliffe Labs. Results: Nine (2.48%) out were screen positive chromosomopathy. point biserial correlation between variables (Free β-hCG - Free Beta Human Chorionic Gonadotrophin, PAPP-A- pregnancy associated plasma protein-A NT-(nuchal translucency) amongst patients with negative statistically significant. There chromosomopathy hCG, MoM, NT MoM whereas them PAPP-A. indicates that higher values hCG lower PAPP-A as seen in significant A age cases seen. McNemar’s indicated reduction when biomarkers added to Trisomy 21 aged >35 years (n=86). 81 eventually screened negative. Conclusions: analyses stresses importance state-of-the-art, noninvasive software help provide predictive outcome, individualized woman.